SigInt project is a command-line software tool that can be used to find and rank mammalian proteins/genes.
The inputs to the program are: (a) a seed list of human Entrez Gene gene symbols, (b) a background networks in SIG format, and (c) a name for the output file (web-page file name with the htm extension). SigInt outputs a sorted list of genes/proteins that interacts with components from the seed list. These components are sorted by a z-score that measures the specificity of these intermediate components to interact with the genes/proteins from the seed list.
SigInt can be run on Linux, Mac and Windows operating systems and it requires a background network text file in SIG format.
Extract the archive
chmod +x sigint_lnx.exe