MELTING v4.2h

MELTING is a program that computes, for a nucleic acid duplex, the enthalpy, the entropy and the melting temperature.

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LICENSE TYPE:
GPL (GNU General Public License) 
USER RATING:
3.6/5 15
DEVELOPED BY:
Nicolas Le Novère
HOMEPAGE:
www.ebi.ac.uk
CATEGORY:
ROOT \ Science and Engineering \ Chemistry
MELTING is a program that computes, for a nucleic acid duplex, the enthalpy, the entropy and the melting temperature of the helix-coil transitions. Three types of hybridization are possible: DNA/DNA, DNA/RNA, and RNA/RNA. The program first computes the hybridization enthalpy and entropy from the elementary parameters of each Crick's pair by the nearest-neighbor method. Then the melting temperature is computed. The set of thermodynamic parameters can be easily changed, for instance following an experimental breakthrough. MELTING is a free program (free as in freedom). It is coded in ISO C and can be compiled on any operating system. Some perl scripts are provided to show how melting can be used as a block to construct more ambitious tools.

INSTALLATION:

Some pre-compiled binaries are located in the directory BIN. If no binary suitable for your OS is provided, or if you want to compile the programme
yourself (a good idea), edit the file 'SRC/makefile' to suit your needs (particularly the default path for the files containing the nearest- neighbor parameters). Please send me a copy of the binary if it is not already in the BIN
directory (send also the makefile).

Copy the file `makefile.unices' as `makefile'. Type `make' to compile the program. Type `make install' to install the files in the proper directories specified within the makefile. Type `make clean' to wash out the useless files.
The manpage melting.1 is moved in the proper location during the installation. The other files can stay in DOC or the entire DOC directory can be moved under the name melting in /usr/doc or an equivalent directory.

Last updated on March 16th, 2008

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